How it Works

The new generation of topical pain cream.
Inspired by nature, clinically proven.

awaye embodies a new generation of relief from chronic and acute pain. Its unique formulation combines two active ingredients, capsaicin and ß-caryophyllene, acting on the endocannabinoid system and working in perfect synergy with the body to provide an effective pain relief.

First of its kind
The awaye formulation is the first of its kind offering safe, non-additive, clinically proven pain relief. awaye topical cream doesn’t trick or dull the senses to distract from the pain, but rather it works with the body to relieve the pain at its source.
Unique formulation
awaye has a unique formulation with dual action ingredients that specifically target the endocannabinoid system - a body’s built-in pain and inflammation defense system. The first agentß-caryophyllene, activates specific receptors of this system to help reduce pain without affecting mental functions. This agent is a natural dietary cannabinoid compound found in several essential oils
and clinically proven to reduce pain. 
Blocks the pain
ß-caryophyllene works in conjunction with our second active ingredient -capsaicin - a natural extract from cayenne pepper. Capsaicin decreases the levels of a specific chemical that sends pain signals to the brain. Capsaicin not only helps block pain messages in the body but it is also creates a slight heating effect which in itself has a therapeutic benefit.

awaye is non-addictive, non-irritating,
and approved by Health Canada as a natural health product.

awaye and the Endocannabinoid System

There are a number of pain defense systems that operate in the body. One of them is called the Endocannabinoid System or ECS for short. The ECS is a complex system of internal communication. It is present throughout the body and interacts constantly with other systems, including the endocrine, immune, circulatory and lymphatic systems. It consists of cannabinoid receptors called CB1 and CB2, located on the surface of cells, as well as molecules named “endocannabinoids”, which humans produce naturally and that are able to bind to these receptors. This specific link, such as a key opening a lock, will activate various reactions within the body. The main function of this system is to react to different “stresses” in order to allow the internal environment to maintain its equilibrium state, which is called homeostasis. The latest research shows that alteration of ECS function can contribute to pain and inflammation.

What separates awaye from other topical analgesic products currently available on the market is its unique dual action formula that specifically targets the body's endocannabinoid system.

The first agent in awayeß-caryophyllene, is a natural dietary cannabinoid compound found in several essential oils, including rosemary, oregano, hops, cloves, cinnamon, black pepper and cannabis. It is one of the first currently known natural compounds acting specifically on the CB2 receptors, hence its ability to activate the endocannabinoid system for the relief of pain and inflammation. 

The second agent, capsaicin, is the active component of cayenne pepper (Cap- sicum annuum/frutescens). Used externally, it blocks certain chemical messages of the body (substance P, agent present in the peripheral nerves), which normally transmit the sensation of pain. In addition, its “heating” action stimulates local circulation by bringing blood to the surface of the skin, improving oxygenation and enhancing the elimination of toxins, thus reducing local tissue congestion.

First of its kind, this novel formulation is therefore able to fight pain in two complementary ways.

The location of CB1 and CB2 receptors in the body

CB1 Receptors
These are located primarily in the nervous system and are the receptors that, when activated, lead to the psychotropic effects (the "high”) one associates with marihuana.
Vascular System
Reproductive Organs
Gastrointestinal Track
CB2 Receptors
These are mainly located in the immune system and, when activated, can assist with relieving pain and inflammation but without affecting mental functions.
CB1 & CB2 Receptors
The following regions contain both the CB1 and CB2 receptors.
Immune System
Bone Marrow
How Awaye Helps
Over the last decade, Panag scientists and medical doctors have been researching ways to exploit the ECS in order to find new ways to treat pain and inflammation. awaye leverages the body’s ECS to fight pain and inflammation. awaye is a dual agent formula that specifically activates the body’s CB2 receptors to relieve pain and inflammation, while also activating the CB1 receptors to reduce pain transmission. The result is the fast & effective relief of pain without affecting mental functions and without the addictive properties of other pain medications.
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